I have a project which I inherited some time ago which was v6 and I have recently upgraded it to v7.5.2 and the backoffice is now dead. The project uses Autofac.Mvc5which I understand may be part of the issue here so hoping someone can spot the issue in the configuration for the site. The full exception is as follows and doesn't actually make it into the log file:

"Message":"An error has occurred.",
"ExceptionMessage":"Object reference not set to an instance of an object.",
"ExceptionType":"System.NullReferenceException",
"StackTrace":"   at Umbraco.Web.Trees.ApplicationTreeExtensions.TryLoadFromControllerTree(ApplicationTree appTree, String id, FormDataCollection formCollection, HttpControllerContext controllerContext)\r\n   at Umbraco.Web.Trees.ApplicationTreeController.<GetRootForSingleAppTree>d__17.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at Umbraco.Web.Trees.ApplicationTreeController.<GetApplicationTrees>d__4.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Threading.Tasks.TaskHelpersExtensions.<CastToObject>d__3`1.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Web.Http.Controllers.ApiControllerActionInvoker.<InvokeActionAsyncCore>d__0.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Web.Http.Filters.ActionFilterAttribute.<CallOnActionExecutedAsync>d__5.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Web.Http.Filters.ActionFilterAttribute.<CallOnActionExecutedAsync>d__5.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Web.Http.Filters.ActionFilterAttribute.<ExecuteActionFilterAsyncCore>d__0.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Web.Http.Filters.ActionFilterAttribute.<CallOnActionExecutedAsync>d__5.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Web.Http.Filters.ActionFilterAttribute.<CallOnActionExecutedAsync>d__5.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Web.Http.Filters.ActionFilterAttribute.<ExecuteActionFilterAsyncCore>d__0.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Web.Http.Filters.ActionFilterAttribute.<CallOnActionExecutedAsync>d__5.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Web.Http.Filters.ActionFilterAttribute.<CallOnActionExecutedAsync>d__5.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Web.Http.Filters.ActionFilterAttribute.<ExecuteActionFilterAsyncCore>d__0.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Web.Http.Controllers.ActionFilterResult.<ExecuteAsync>d__2.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Web.Http.Filters.AuthorizationFilterAttribute.<ExecuteAuthorizationFilterAsyncCore>d__2.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Web.Http.Filters.AuthorizationFilterAttribute.<ExecuteAuthorizationFilterAsyncCore>d__2.MoveNext()\r\n--- End of stack trace from previous location where exception was thrown ---\r\n   at System.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task)\r\n   at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task)\r\n   at System.Web.Http.Dispatcher.HttpControllerDispatcher.<SendAsync>d__1.MoveNext()"

I'm not sure how I can go about tracking down what tree in particular is triggering this.

Relevant parts of the Autofac config as follows:

this._builder = new ContainerBuilder();

// Register umbraco context
this._builder.Register(c => UmbracoContext.Current).AsSelf();
this._builder.RegisterType<ApplicationContext>().AsSelf();

// Register mvc & api controllers
this._builder.RegisterControllers(Assembly.GetExecutingAssembly());
this._builder.RegisterApiControllers(typeof(MyApiService).Assembly);
this._builder.RegisterModelBinders(Assembly.GetExecutingAssembly());
this._builder.RegisterModelBinderProvider();
this._builder.RegisterFilterProvider();
this.RegisterPerLifetimeConnections();
this.RegisterRepositories();
this.RegisterServices();

var container = this._builder.Build();

DependencyResolver.SetResolver(new AutofacDependencyResolver(container));

// Setup the webapi dependency resolver to use autofac
var resolver = new AutofacWebApiDependencyResolver(container);
GlobalConfiguration.Configuration.DependencyResolver = resolver;

Thanks, Simon