We have Umbraco running in a multi-node environment.

Recently (with 7.5.4), Umbraco is often crashing when publishing new content. It will keep crashing several times before the application comes back to normal. Furthermore, all the nodes crash, so the load balancer does not help.

2016-11-22 13:23:15,721 [P6352/D4/T135] INFO  umbraco.content - Load Xml from file...
 2016-11-22 13:23:15,722 [P6352/D4/T135] ERROR umbraco.content - Failed to load Xml from file.
System.IO.IOException: The process cannot access the file 'C:\Web\fee-production\App_Data\umbraco.config' because it is being used by another process.
   at System.IO.__Error.WinIOError(Int32 errorCode, String maybeFullPath)
   at System.IO.FileStream.Init(String path, FileMode mode, FileAccess access, Int32 rights, Boolean useRights, FileShare share, Int32 bufferSize, FileOptions options, SECURITY_ATTRIBUTES secAttrs, String msgPath, Boolean bFromProxy, Boolean useLongPath, Boolean checkHost)
   at System.IO.FileStream..ctor(String path, FileMode mode, FileAccess access, FileShare share)
   at umbraco.content.LoadXmlFromFile()
 2016-11-22 13:23:16,416 [P6352/D4/T164] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [KeepAlive] Terminating
 2016-11-22 13:23:16,416 [P6352/D4/T164] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [KeepAlive] Waiting for tasks to complete
 2016-11-22 13:23:16,424 [P6352/D4/T164] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [ScheduledPublishing] Terminating
 2016-11-22 13:23:16,424 [P6352/D4/T164] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [ScheduledPublishing] Waiting for tasks to complete
 2016-11-22 13:23:16,653 [P6352/D4/T71] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [ScheduledPublishing] Tasks completed, terminated
 2016-11-22 13:23:16,653 [P6352/D4/T88] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [KeepAlive] Tasks completed, terminated
 2016-11-22 13:23:21,189 [P6352/D4/T43] INFO  umbraco.content - Saved Xml to file.
 2016-11-22 13:23:21,509 [P6352/D4/T164] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [ScheduledTasks] Terminating
 2016-11-22 13:23:21,509 [P6352/D4/T164] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [ScheduledTasks] Waiting for tasks to complete
 2016-11-22 13:23:21,509 [P6352/D4/T164] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [LogScrubber] Terminating
 2016-11-22 13:23:21,509 [P6352/D4/T164] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [LogScrubber] Waiting for tasks to complete
 2016-11-22 13:23:21,509 [P6352/D4/T164] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [Umbraco.Web.Scheduling.IBackgroundTask] Terminating
 2016-11-22 13:23:21,509 [P6352/D4/T164] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [Umbraco.Web.Scheduling.IBackgroundTask] Waiting for tasks to complete
 2016-11-22 13:23:21,511 [P6352/D4/T111] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [ScheduledTasks] Tasks completed, terminated
 2016-11-22 13:23:21,513 [P6352/D4/T85] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [LogScrubber] Tasks completed, terminated
 2016-11-22 13:23:21,513 [P6352/D4/T151] INFO  Umbraco.Web.Scheduling.BackgroundTaskRunner - [Umbraco.Web.Scheduling.IBackgroundTask] Tasks completed, terminated
 2016-11-22 13:23:35,122 [P6352/D5/T169] INFO  Umbraco.Core.CoreBootManager - Umbraco 7.5.4 application starting on DEV1

2016-11-22 13:24:02,667 [P6352/D4/T96] INFO  Umbraco.Core.UmbracoApplicationBase - Application shutdown. Details: ConfigurationChange

_shutDownMessage=CONFIG change
HostingEnvironment initiated shutdown
CONFIG change
[Repeat CONFIG change about 5,000 times]
CONFIG change
HostingEnvironment caused shutdown

_shutDownStack=   at System.Environment.GetStackTrace(Exception e, Boolean needFileInfo) 
CONFIG change
HostingEnvironment caused shutdown

_shutDownStack=   at System.Environment.GetStackTrace(Exception e, Boolean needFileInfo)